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Abstract Polyketide synthases (PKSs) are crucial multidomain enzymes in diverse natural product biosynthesis.Parrots use a type I PKS to produce a unique pigment called psittacofulvin in their feathers.In domesticated budgerigars and lovebirds, the same amino acid substitution (R644W) within kaiser copy stands malonyl/acetyltransferase (MAT) domain
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